Recent trials show that some breast cancer patients benefit from treatment with immuno therapies. Immune cells infiltrating breast tumors are also established prognostic factors in some breast cancer sub types. We now face the challenges of identifying those patients most likely to benefit from treatment, how best to combine immun otherapies with conventional therapies and discovering novel immune targets for new treatments. This project will address these questions by using cutting edge multidimensional tissue imaging (imaging mass cytometry) technology to quantify expression of fifty markers simultaneously in breast tumors. This will enable in-depth characterization of the cellular components of the in situ immune response, their spatial relatedness and organisation at the tumor-immune interface. How immune dynamics reflect tumor evolution and treatment response will be evaluated by using pre and post-treatment samples. Extensive training in systems pathology, multidimensional tissue imaging, computational biology and clinical epidemiology will be provided.
Worth of Award
This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and in addition, a stipend of £19,000 per annum, initially for 3 years, with funding for a further year possible as required.
- No nationality restrictions apply to Cancer Research UK funded studentships.
- Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.
How to Apply
All applications need to be made using the University Applicant Portal.
To complete your on-line application, you need to provide the following:
- Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.
- Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the ‘Research summary’ text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the ‘Research Supervisor’ text box. Please describe your past ‘Research experience’ in the appropriate text box.
- Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.
- Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.
Deadline: The closing date for applications is November 15, 2019, with interviews expected to take place in December/January. Please quote reference SW20866 on your application and in any correspondence about this vacancy.